![]() Daytime drowsiness (OR = 2.53, 95% CI 1.14–5.64, P = 0.02) and decreased appetite (OR = 2.81, 95% CI 1.14–6.92, P = 0.02) occurred with greater frequency in the trazodone group as compared to the control group, and the differences were significant. Risk of bias was low in 5 trials (45.5%), and was moderate in 6 (54.5%). Eleven randomized controlled trials were selected and participants were 466. The mean differences (MD) or standardized mean differences (SMD) and odds ratios (OR) with 95% confidence intervals (CIs) were estimated. When I 2 ≥ 50%, the random effects model was used. When I 2 < 50%, the fixed effects model was used. The results of quality of evidence assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. RoB 2 was used to evaluate the risk of bias. RCTs in patients with insomnia disorder applying trazodone in one arm of interventions at least 1 week, and reporting PSG parameters in the outcomes were eligible. PubMed, EMBASE, Web of Science, PsycINFO, Cochrane Library, Chinese Biomedical Literature Database (SinoMed), China National Knowledge Infrastructure, Wanfang Database, and the China Science and Technology Journal Database were searched for articles published between inception and June 2022. To assess the efficacy of trazodone in altering the polysomnographic sleep architecture in insomnia disorder so that sleep can be facilitated. Identifying how trazodone impacts the performance of polysomnographic sleep architecture in insomnia disorder will provide additional data that can be used to guide clinical application. doi:10.Trazodone has been widely prescribed for off-label use as a sleep aid. An update on the use of sedative-hypnotic medications in psychiatric disorders. Antidepressants, anxiolytics, and hypnotics in pregnancy and lactation. Unintentional trazodone overdoses in children ≤6 years of age: data from poison center over a period of 16 years. Antidepressants and cardiovascular adverse events: A narrative review. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: An American Academy of Sleep Medicine clinical practice guideline. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Histamine in the regulation of wakefulness. Rediscovering trazodone for the treatment of major depressive disorder. ![]() Trazodone for insomnia: a systematic review.
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